Anaxomics has created a dictionary that translates clinical and medical terms into molecular biology data, effectively linking the molecular and the clinical worlds. This dictionary, called Biological Effectors Database (BED), relates biological processes (adverse events of drugs, drug indications, diseases …) with the proteins most closely associated to them. Thus, it acts as a translator of clinical phenotypes into terms comprehensible for mathematical models, and conversely allows the translation of molecular measures toward clinical outcomes.

biological-effectors-2

A team of highly qualified experts collate and review biological, pharmacological and medical information, including information about genes and proteins, pathologies, adverse events, pathways, metabolism, results from clinical trials, microarrays, biomarker information, etc. More than 15,000 scientific publications and some of the most widely accepted databases (KEGG, UniProt, DrugBank, SIDER, GEO, IntAct, OMIM, Reactome, PDB …) are compiled in this dictionary, constituting an ever-increasing large amount of curated data that is continuously updated to include the most recent known data.

At present, the BED contains more than 200 biological effects (pathological conditions) connected to more than 600 physiological mechanisms (motives) and to more than 2500 proteins (effectors).

effectors